- Third-party tested
- >99% purity
- 99%+ purity or full refund
- Same-day shipping
MOTS-c
MOTS-c — Mitochondrial-derived peptide (mtDNA 12S rRNA encoded)
Independently verified — COA posting for the current batch.
Every batch is third-party tested by HPLC and mass spectrometry. See all certificates of analysis
- Same-day shipping before 12pm
- Free US shipping over $100
- 99%+ purity or full refund
- Secure checkout
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded by the mitochondrial genome within the 12S rRNA region. It is one of the most actively studied mitochondrial-derived peptides (MDPs) and has been the focus of research into cellular energy homeostasis, AMPK pathway activation, and the regulation of metabolic flexibility. Circulating MOTS-c levels decline with age in mammals, fueling investigations into its role in age-related metabolic decline.
Key research areas
Studied for AMPK activation, improved insulin sensitivity, and glucose homeostasis in rodent models.
Investigated for its role in promoting mitochondrial function and oxidative phosphorylation capacity.
Preclinical research suggests MOTS-c partially mimics the metabolic effects of physical training in murine models.
Endogenous MOTS-c levels decline with age; supplementation in animal studies has shown extended healthspan markers.
- CAS number
- 1627580-64-6
- Molecular formula
- C₇₉H₁₃₃N₂₁O₂₂S₂
- Molecular weight
- 1820.21
- Purity
- ≥99.0%
- PubChem ID
- 117768796
Metabolic regulation
Studied for AMPK activation, improved insulin sensitivity, and glucose homeostasis in rodent models.
Mitochondrial biogenesis
Investigated for its role in promoting mitochondrial function and oxidative phosphorylation capacity.
Exercise mimetic
Preclinical research suggests MOTS-c partially mimics the metabolic effects of physical training in murine models.
Longevity & aging
Endogenous MOTS-c levels decline with age; supplementation in animal studies has shown extended healthspan markers.
- Lee C et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443-454.
- Kim SJ et al. (2018). Mitochondrially derived peptides as novel regulators of metabolism. Journal of Physiology, 595(21), 6613-6621.
- Reynolds JC et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12, 470.
Store lyophilized peptide at −20°C, protected from light and moisture. Once reconstituted with bacteriostatic water, store at 2–8°C and use within 28 days.
Specifications
- CAS
- 1627580-64-6
- Formula
- C₇₉H₁₃₃N₂₁O₂₂S₂
- MW
- 1820.21
- Purity
- ≥99.0%
Our process
Lyophilization
Each peptide is freeze-dried under controlled vacuum conditions, ensuring long-term stability and consistent potency across every vial.
Verified purity
Every batch is tested by independent third-party labs using HPLC and mass spectrometry. Certificates of analysis are published for each product.
Same-day fulfillment
Orders placed before 12pm ship the same business day. We use insulated packaging and cold packs where required.
Frequently asked questions
Each vial contains lyophilized peptide powder at the labeled dosage. No solvents, fillers, or preservatives.
Every batch is HPLC-tested. Certificate of Analysis (COA) and HPLC report are available on the product page.
Store the lyophilized peptide at −20°C, dry and dark. See the Storage tab for product-specific details.
United States only, in temperature-controlled packaging. 3–5 day standard or 1–2 day express.
No. All products are for laboratory and research use only (RUO) and are not intended for human or veterinary use.
